Protein profile

PA3790

copper transport outer membrane porin OprC

Genome: NC_002516.2

Gene: CAZ10_17670 GNQ48_05360 oprC PA3790 Structure source: Experimental + AlphaFold UniProt G3XD89 UniProt P72121
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Amino acids 723
Annotations 4
Features 19
PDB binders 7
Druggability 0.446

Overview

Basic information about this protein and its source genome.

Accession
PA3790
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
CAZ10_17670 GNQ48_05360 oprC PA3790
Status
annotated
Amino acids
723
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046872 Binding to a metal ion. GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in). GO:0044718 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.446
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0046872 Binding to a metal ion.
  • GO:0015344 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in).
  • GO:0044718 The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
193 723 Gene3D G3DSA:2.40.170.20 -
193 723 InterPro IPR036942 TonB-dependent receptor-like, beta-barrel domain superfamily
47 53 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
82 723 NCBIfam TIGR01778 TonB-dependent copper receptor
82 723 InterPro IPR010100 TonB-dependent copper receptor
79 723 CDD cd01347 ligand_gated_channel
1 53 Phobius SIGNAL_PEPTIDE Signal peptide region
54 723 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
35 46 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
74 187 Gene3D G3DSA:2.170.130.10 -
74 187 InterPro IPR037066 TonB-dependent receptor, plug domain superfamily
71 723 SUPERFAMILY SSF56935 Porins
38 723 PANTHER PTHR30069 TONB-DEPENDENT OUTER MEMBRANE RECEPTOR
38 723 InterPro IPR039426 TonB-dependent receptor-like
91 181 Pfam PF07715 TonB-dependent Receptor Plug Domain
91 181 InterPro IPR012910 TonB-dependent receptor, plug domain
236 721 Pfam PF00593 TonB dependent receptor
236 721 InterPro IPR000531 TonB-dependent receptor-like, beta-barrel
1 34 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

13 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 6FOK
X-ray 1.97 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Viewing
PDB 6Z8S
X-ray 2.37 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8R
X-ray 2.38 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8Z
X-ray 2.56 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z91
X-ray 2.60 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8U
X-ray 2.61 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z99
X-ray 2.68 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8Q
X-ray 2.71 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z9N
X-ray 2.73 Å A,B,C,D
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8Y
X-ray 2.78 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z8T
X-ray 2.86 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6FOM
X-ray 2.90 Å A,B
100.0% 1-723
PDBe RCSB PDBj File
Loaded
PDB 6Z9Y
X-ray 2.95 Å A,B,C,D
100.0% 1-723
PDBe RCSB PDBj File
Loaded
AlphaFold PA3790
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.446

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 18.62 0.826
2 15.85 0.764
3 7.31 0.381
4 6.92 0.357
5 4.77 0.211

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

57 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
C8E
6FOK 1.97 Å Open crystal
306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.