Protein profile

PA3800

outer membrane protein assembly factor BamB

Genome: NC_002516.2

Gene: bamB PA3800 Structure source: Experimental + AlphaFold UniProt Q9HXJ7
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Amino acids 380
Annotations 4
Features 30
PDB binders 0
Druggability 0.798

Overview

Basic information about this protein and its source genome.

Accession
PA3800
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
bamB PA3800
Status
annotated
Amino acids
380
Structure source
Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.798
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
  • GO:0051205 The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
  • GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records
Show feature table
Start End DB Term Name
16 380 Gene3D G3DSA:2.130.10.10 -
16 380 InterPro IPR015943 WD40/YVTN repeat-like-containing domain superfamily
75 305 Pfam PF13360 PQQ-like domain
75 305 InterPro IPR002372 Pyrrolo-quinoline quinone repeat
5 377 NCBIfam TIGR03300 outer membrane protein assembly factor BamB
5 377 InterPro IPR017687 Outer membrane protein assembly factor BamB
24 380 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 369 SUPERFAMILY SSF50998 Quinoprotein alcohol dehydrogenase-like
29 369 InterPro IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
27 371 PANTHER PTHR34512 CELL SURFACE PROTEIN
1 19 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 19 SignalP_EUK SignalP-noTM SignalP-noTM
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
1 379 Hamap MF_00923 Outer membrane protein assembly factor BamB [bamB].
1 379 InterPro IPR017687 Outer membrane protein assembly factor BamB
101 133 SMART SM00564 ire1_9
101 133 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
187 218 SMART SM00564 ire1_9
187 218 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
317 348 SMART SM00564 ire1_9
317 348 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
142 173 SMART SM00564 ire1_9
142 173 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
238 269 SMART SM00564 ire1_9
238 269 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
62 93 SMART SM00564 ire1_9
62 93 InterPro IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4HDJ
X-ray 1.85 Å A
95.0% 20-380
PDBe RCSB PDBj File
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AlphaFold PA3800
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.798
2 0.494
6 0.266

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.32 0.8
2 0.55 0.0