Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3804
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3804
Status: annotated
Amino acids: 347
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006352 The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.626

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MMKAPQPEVVATASRQNPGETLRQAREQKGLSLSQVAGQLNLTENSLRQLENGAFDKLPGHTFSRGYIRAYAKLMGLDQAELVNSFDHFTGTNASGSTVQSLGRVAEPVRLSRNVLRIVSLLLLALLIGFGYFWWQEHSARTPETAGLSLEHVEVESADGTTEIHTLDEPEDQAVIEAQKEGEQAPAEVSPEVAAQAEGAPPVASEGAQVPAAPAQGTPAAPQQPVTAAPAGTAPAPGTAPAVPATASPAAPPAPSEPAAAPVVAGEGQGVVKVQFVADCWTQVTDANGKVLVSALKRKGDSLELAGKAPLELRLGFARGAQVSYNGQPVDVTPFVRGETARLKVGQ

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006352 The initial step of transcription, consisting of the assembly of the RNA polymerase preinitiation complex (PIC) at a gene promoter, as well as the formation of the first few bonds of the RNA transcript. Transcription initiation includes abortive initiation events, which occur when the first few nucleotides are repeatedly synthesized and then released, and ends when promoter clearance takes place.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
272	345	Pfam	PF13464	Domain of unknown function (DUF4115)
272	345	InterPro	IPR025194	Domain of unknown function DUF4115
21	82	SMART	SM00530	mbf_short4
21	82	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
32	58	ProSitePatterns	PS00716	Sigma-70 factors family signature 2.
32	58	InterPro	IPR000943	RNA polymerase sigma-70
136	347	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
10	110	Gene3D	G3DSA:1.10.260.40	-
10	110	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
156	262	MobiDBLite	mobidb-lite	consensus disorder prediction
22	82	ProSiteProfiles	PS50943	Cro/C1-type HTH domain profile.
22	82	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
19	82	CDD	cd00093	HTH_XRE
19	82	InterPro	IPR001387	Cro/C1-type helix-turn-helix domain
114	136	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
156	178	MobiDBLite	mobidb-lite	consensus disorder prediction
1	113	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17	86	SUPERFAMILY	SSF47413	lambda repressor-like DNA-binding domains
17	86	InterPro	IPR010982	Lambda repressor-like, DNA-binding domain superfamily
21	81	Pfam	PF13413	Helix-turn-helix domain
114	135	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	20	MobiDBLite	mobidb-lite	consensus disorder prediction
6	346	PANTHER	PTHR34475	-

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3804	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.513

PA3804