Protein profile

PA3810

chaperone protein HscA

Genome: NC_002516.2

Gene: hscA PA3810 Structure source: AlphaFold UniProt Q51382
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Amino acids 619
Annotations 10
Features 42
PDB binders 4
Druggability 0.417

Overview

Basic information about this protein and its source genome.

Accession
PA3810
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
hscA PA3810
Status
annotated
Amino acids
619
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0140662 Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. GO:0031072 Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
45.055
Human E-value
6.980000000000001e-37
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.417
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

10 GO

Gene Ontology (GO)

10
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0016887 Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
  • GO:0140662 Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
  • GO:0031072 Binding to a heat shock protein, a protein synthesized or activated in response to heat shock.
  • GO:0044183 Binding to a protein or a protein-containing complex to assist the protein folding process.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0016226 The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
  • GO:0042026 The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Sequence Features

Domain/signature hits from InterPro and related databases.

42 records
Show feature table
Start End DB Term Name
384 535 SUPERFAMILY SSF100920 Heat shock protein 70kD (HSP70), peptide-binding domain
384 535 InterPro IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
22 205 FunFam G3DSA:3.30.420.40:FF:000046 Chaperone protein HscA
380 519 FunFam G3DSA:2.60.34.10:FF:000005 Chaperone protein HscA homolog
21 548 PANTHER PTHR19375 HEAT SHOCK PROTEIN 70KDA
21 548 InterPro IPR013126 Heat shock protein 70 family
332 346 ProSitePatterns PS01036 Heat shock hsp70 proteins family signature 3.
332 346 InterPro IPR018181 Heat shock protein 70, conserved site
19 197 SUPERFAMILY SSF53067 Actin-like ATPase domain
19 197 InterPro IPR043129 ATPase, nucleotide binding domain
21 616 NCBIfam TIGR01991 Fe-S protein assembly chaperone HscA
21 616 InterPro IPR010236 ISC system FeS cluster assembly, HscA chaperone
526 546 Coils Coil Coil
21 600 Pfam PF00012 Hsp70 protein
21 600 InterPro IPR013126 Heat shock protein 70 family
1 617 Hamap MF_00679 Chaperone protein HscA [hscA].
1 617 InterPro IPR010236 ISC system FeS cluster assembly, HscA chaperone
24 31 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1.
24 31 InterPro IPR018181 Heat shock protein 70, conserved site
504 615 SUPERFAMILY SSF100934 Heat shock protein 70kD (HSP70), C-terminal subdomain
504 615 InterPro IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
200 376 SUPERFAMILY SSF53067 Actin-like ATPase domain
200 376 InterPro IPR043129 ATPase, nucleotide binding domain
20 375 CDD cd10236 HscA_like_NBD
20 375 InterPro IPR042039 HscA chaperone, nucleotide-binding domain
205 218 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2.
205 218 InterPro IPR018181 Heat shock protein 70, conserved site
520 616 Gene3D G3DSA:1.20.1270.10 -
520 616 InterPro IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
385 404 PRINTS PR00301 70kDa heat shock protein signature
48 60 PRINTS PR00301 70kDa heat shock protein signature
329 345 PRINTS PR00301 70kDa heat shock protein signature
360 380 PRINTS PR00301 70kDa heat shock protein signature
466 482 PRINTS PR00301 70kDa heat shock protein signature
211 221 PRINTS PR00301 70kDa heat shock protein signature
152 172 PRINTS PR00301 70kDa heat shock protein signature
20 33 PRINTS PR00301 70kDa heat shock protein signature
379 517 Gene3D G3DSA:2.60.34.10 Substrate Binding Domain Of DNAk; Chain A, domain 1
379 517 InterPro IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
238 311 Gene3D G3DSA:3.90.640.10 Actin; Chain A, domain 4
22 374 Gene3D G3DSA:3.30.420.40 -
194 361 Gene3D G3DSA:3.30.420.40 -

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3810
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.417

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

82 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
3TR
5FPE
P54652 84.1 Da LogP -0.61 TPSA 67.6 ✓ Ro5 ✓ Clean c1[nH]nc(n1)N
ANP
3KVG
Q5CPP8 506.2 Da LogP -2.06 TPSA 281.9 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…
IWT
5FPM
P54652 178.2 Da LogP 2.03 TPSA 38.9 ✓ Ro5 ✓ Clean c1ccc(cc1)c2nnc(o2)S
NO7
6P2U
P38646 465.3 Da LogP -1.28 TPSA 218.6 2 viol. ✓ Clean C#CCNc1c2c(ncn1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.