Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3811
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3811 hscB
Status: annotated
Amino acids: 173
Structure source: AlphaFold

GO

GO:1990230 A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER. GO:0001671 Binds to and increases the activity of an ATP hydrolysis activity. GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0044571 The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. GO:0051259 The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer. GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 35.211
Human E-value: 1.89e-07
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.805

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:1990230 A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor), which may be a target protein or another Fe-S assembly complex. In humans, it consists of HSPA9, HSCB, GLRX5, ABCB7 and GFER.
GO:0001671 Binds to and increases the activity of an ATP hydrolysis activity.
GO:0051087 Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
GO:0044571 The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster.
GO:0051259 The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Sequence Features

Domain/signature hits from InterPro and related databases.

27 records

Show feature table

Start	End	DB	Term	Name
19	65	CDD	cd06257	DnaJ
19	65	InterPro	IPR001623	DnaJ domain
5	77	ProSiteProfiles	PS50076	dnaJ domain profile.
5	77	InterPro	IPR001623	DnaJ domain
4	69	SMART	SM00271	dnaj_3
4	69	InterPro	IPR001623	DnaJ domain
6	82	Gene3D	G3DSA:1.10.287.110	DnaJ domain
6	82	InterPro	IPR036869	Chaperone J-domain superfamily
85	173	Gene3D	G3DSA:1.20.1280.20	-
85	173	InterPro	IPR036386	HscB, C-terminal domain superfamily
4	172	Hamap	MF_00682	Co-chaperone protein HscB [hscB].
4	172	InterPro	IPR004640	Co-chaperone Hsc20
19	73	Pfam	PF00226	DnaJ domain
19	73	InterPro	IPR001623	DnaJ domain
84	173	FunFam	G3DSA:1.20.1280.20:FF:000005	Co-chaperone protein HscB homolog
17	171	NCBIfam	TIGR00714	Fe-S protein assembly co-chaperone HscB
17	171	InterPro	IPR004640	Co-chaperone Hsc20
6	77	SUPERFAMILY	SSF46565	Chaperone J-domain
6	77	InterPro	IPR036869	Chaperone J-domain superfamily
89	164	Pfam	PF07743	HSCB C-terminal oligomerisation domain
89	164	InterPro	IPR009073	Co-chaperone HscB, C-terminal oligomerisation domain
157	173	Coils	Coil	Coil
6	82	FunFam	G3DSA:1.10.287.110:FF:000128	Co-chaperone protein HscB homolog
5	167	PANTHER	PTHR14021	IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB
5	167	InterPro	IPR004640	Co-chaperone Hsc20
84	173	SUPERFAMILY	SSF47144	HSC20 (HSCB), C-terminal oligomerisation domain
84	173	InterPro	IPR036386	HscB, C-terminal domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3811	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.805
7				0.43

PA3811