Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3830
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3830
Status: annotated
Amino acids: 270
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.94

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records

Show feature table

Start	End	DB	Term	Name
12	219	SUPERFAMILY	SSF51182	RmlC-like cupins
12	219	InterPro	IPR011051	RmlC-like cupin domain superfamily
163	267	FunFam	G3DSA:1.10.10.60:FF:000132	AraC family transcriptional regulator
219	260	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
219	260	InterPro	IPR018062	HTH domain AraC-type, conserved site
28	121	CDD	cd06124	cupin_NimR-like_N
13	265	PANTHER	PTHR11019	HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
9	102	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
9	102	InterPro	IPR014710	RmlC-like jelly roll fold
169	266	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
169	266	InterPro	IPR018060	DNA binding HTH domain, AraC-type
218	263	SUPERFAMILY	SSF46689	Homeodomain-like
218	263	InterPro	IPR009057	Homeobox-like domain superfamily
33	93	Pfam	PF07883	Cupin domain
33	93	InterPro	IPR013096	Cupin 2, conserved barrel
233	248	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
233	248	InterPro	IPR020449	Transcription regulator HTH, AraC- type
248	264	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
248	264	InterPro	IPR020449	Transcription regulator HTH, AraC- type
188	264	Pfam	PF12833	Helix-turn-helix domain
188	264	InterPro	IPR018060	DNA binding HTH domain, AraC-type
166	268	Gene3D	G3DSA:1.10.10.60	-
182	264	SMART	SM00342	aracneu4
182	264	InterPro	IPR018060	DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3830	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.94

PA3830