Protein profile

PA3842

chaperone

Genome: NC_002516.2

Gene: PA3842 ALP65_02350 GUL26_00895 Structure source: Experimental + AlphaFold UniProt G3XD93 UniProt Q51450
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Amino acids 116
Annotations 1
Features 17
PDB binders 0
Druggability 0.481

Overview

Basic information about this protein and its source genome.

Accession
PA3842
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3842 ALP65_02350 GUL26_00895
Status
annotated
Amino acids
116
Structure source
Experimental + AlphaFold
GO
GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.481
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0030254 The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
8 116 Pfam PF05932 Tir chaperone protein (CesT) family
1 116 PIRSF PIRSF011271 SycE
1 116 InterPro IPR005416 Type III secretion chaperone SycE
1 116 Gene3D G3DSA:3.30.1460.10 -
30 51 PRINTS PR01596 Gram-negative bacterial type III secretion SycE chaperone signature
30 51 InterPro IPR005416 Type III secretion chaperone SycE
5 28 PRINTS PR01596 Gram-negative bacterial type III secretion SycE chaperone signature
5 28 InterPro IPR005416 Type III secretion chaperone SycE
60 76 PRINTS PR01596 Gram-negative bacterial type III secretion SycE chaperone signature
60 76 InterPro IPR005416 Type III secretion chaperone SycE
79 97 PRINTS PR01596 Gram-negative bacterial type III secretion SycE chaperone signature
79 97 InterPro IPR005416 Type III secretion chaperone SycE
97 115 PRINTS PR01596 Gram-negative bacterial type III secretion SycE chaperone signature
97 115 InterPro IPR005416 Type III secretion chaperone SycE
8 116 InterPro IPR010261 Tir chaperone protein (CesT) family
5 116 CDD cd17029 T3SC_IA_SycE_SpcS-like
5 115 SUPERFAMILY SSF69635 Type III secretory system chaperone-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4JMF
X-ray 2.10 Å B,C
100.0% 1-116
PDBe RCSB PDBj File
Viewing
PDB 6JNP
X-ray 2.26 Å B,C,E,F
100.0% 1-116
PDBe RCSB PDBj File
Loaded
AlphaFold PA3842
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.481
3 0.367