Protein profile

PA3854

GIY-YIG nuclease superfamily protein

Genome: NC_002516.2

Gene: PA3854 Structure source: AlphaFold UniProt Q9HXF2

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Amino acids 104

Annotations 0

Features 10

PDB binders 0

Druggability 0.592

Overview

Basic information about this protein and its source genome.

Accession: PA3854
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3854
Status: annotated
Amino acids: 104
Structure source: AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.592

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
13	88	ProSiteProfiles	PS50164	GIY-YIG domain profile.
13	88	InterPro	IPR000305	GIY-YIG endonuclease
15	82	CDD	cd10456	GIY-YIG_UPF0213
14	92	PANTHER	PTHR34477	UPF0213 PROTEIN YHBQ
10	95	Gene3D	G3DSA:3.40.1440.10	-
10	95	InterPro	IPR035901	GIY-YIG endonuclease superfamily
14	84	Pfam	PF01541	GIY-YIG catalytic domain
14	84	InterPro	IPR000305	GIY-YIG endonuclease
15	83	SUPERFAMILY	SSF82771	GIY-YIG endonuclease
15	83	InterPro	IPR035901	GIY-YIG endonuclease superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3854	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
2				0.592