Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3867
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3867
Status: annotated
Amino acids: 191
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA. GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.888

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0000150 Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA.
GO:0004803 Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element.
GO:0015074 The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
GO:0006310 Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
GO:0006313 A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
1	124	Gene3D	G3DSA:3.40.50.1390	-
1	124	InterPro	IPR036162	Resolvase-like, N-terminal catalytic domain superfamily
1	125	FunFam	G3DSA:3.40.50.1390:FF:000001	DNA recombinase
2	136	SMART	SM00857	resolvase_6
2	136	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
138	180	Pfam	PF02796	Helix-turn-helix domain of resolvase
138	180	InterPro	IPR006120	Resolvase, HTH domain
3	135	Pfam	PF00239	Resolvase, N terminal domain
3	135	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
3	141	PANTHER	PTHR30461	DNA-INVERTASE FROM LAMBDOID PROPHAGE
138	186	Gene3D	G3DSA:1.10.10.60	-
55	67	ProSitePatterns	PS00398	Site-specific recombinases signature 2.
55	67	InterPro	IPR006118	Recombinase, conserved site
1	135	SUPERFAMILY	SSF53041	Resolvase-like
1	135	InterPro	IPR036162	Resolvase-like, N-terminal catalytic domain superfamily
1	134	ProSiteProfiles	PS51736	Resolvase/invertase-type recombinase catalytic domain profile.
1	134	InterPro	IPR006119	Resolvase, N-terminal catalytic domain
2	121	CDD	cd03768	SR_ResInv
138	181	SUPERFAMILY	SSF46689	Homeodomain-like
138	181	InterPro	IPR009057	Homeobox-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3867	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.888
1				0.275

PA3867