Protein profile

PA3873

respiratory nitrate reductase subunit delta

Genome: NC_002516.2

Gene: CAZ10_29340 GUL26_00760 narJ IPC1295_13980 PAERUG_P19_London_7_VIM_2_05_10_06659 narW GNQ48_14815 PA3873 L4V69_08990 Structure source: AlphaFold UniProt G3XCY9 UniProt O54045
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Amino acids 246
Annotations 4
Features 11
PDB binders 0
Druggability 0.54

Overview

Basic information about this protein and its source genome.

Accession
PA3873
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
CAZ10_29340 GUL26_00760 narJ IPC1295_13980 PAERUG_P19_London_7_VIM_2_05_10_06659 narW GNQ48_14815 PA3873 L4V69_08990
Status
annotated
Amino acids
246
Structure source
AlphaFold
GO
GO:0016530 Binding to and delivering metal ions to a target protein. GO:0051082 Binding to an unfolded protein. GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex. GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.54
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016530 Binding to and delivering metal ions to a target protein.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0051131 The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
  • GO:0042128 The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
1 245 PANTHER PTHR43680 NITRATE REDUCTASE MOLYBDENUM COFACTOR ASSEMBLY CHAPERONE
1 245 InterPro IPR003765 Nitrate reductase chaperone, NarJ
207 227 MobiDBLite mobidb-lite consensus disorder prediction
40 160 Pfam PF02613 Nitrate reductase delta subunit
40 160 InterPro IPR020945 DMSO/Nitrate reductase chaperone
201 227 MobiDBLite mobidb-lite consensus disorder prediction
6 166 SUPERFAMILY SSF89155 TorD-like
6 166 InterPro IPR036411 TorD-like superfamily
1 168 Gene3D G3DSA:1.10.3480.10 -
13 164 NCBIfam TIGR00684 nitrate reductase molybdenum cofactor assembly chaperone
13 164 InterPro IPR003765 Nitrate reductase chaperone, NarJ

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3873
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.54
2 0.448