Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3879
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: narL PA3879
Status: annotated
Amino acids: 219
Structure source: AlphaFold

GO

GO:0032993 A macromolecular complex containing both protein and DNA molecules. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.945

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

8 GO

Gene Ontology (GO)

8

GO:0032993 A macromolecular complex containing both protein and DNA molecules.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0001217 A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets.
GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
GO:0000160 A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

30 records

Show feature table

Start	End	DB	Term	Name
173	189	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
173	189	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
189	201	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
189	201	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
159	173	PRINTS	PR00038	LuxR bacterial regulatory protein HTH signature
159	173	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
158	213	Pfam	PF00196	Bacterial regulatory proteins, luxR family
158	213	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
14	130	CDD	cd19931	REC_NarL
12	125	SMART	SM00448	REC_2
12	125	InterPro	IPR001789	Signal transduction response regulator, receiver domain
159	215	CDD	cd06170	LuxR_C_like
159	215	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
5	216	PANTHER	PTHR43214	TWO-COMPONENT RESPONSE REGULATOR
5	216	InterPro	IPR039420	Transcriptional regulatory protein WalR-like
11	143	SUPERFAMILY	SSF52172	CheY-like
11	143	InterPro	IPR011006	CheY-like superfamily
152	217	ProSiteProfiles	PS50043	LuxR-type HTH domain profile.
152	217	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
15	126	Pfam	PF00072	Response regulator receiver domain
15	126	InterPro	IPR001789	Signal transduction response regulator, receiver domain
12	219	Gene3D	G3DSA:3.40.50.2300	-
156	213	SMART	SM00421	luxrmega5
156	213	InterPro	IPR000792	Transcription regulator LuxR, C-terminal
146	218	SUPERFAMILY	SSF46894	C-terminal effector domain of the bipartite response regulators
146	218	InterPro	IPR016032	Signal transduction response regulator, C-terminal effector
13	129	ProSiteProfiles	PS50110	Response regulatory domain profile.
13	129	InterPro	IPR001789	Signal transduction response regulator, receiver domain
173	200	ProSitePatterns	PS00622	LuxR-type HTH domain signature.
173	200	InterPro	IPR000792	Transcription regulator LuxR, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3879	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.945

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

2 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
4QT	4ZMS	Q8DNC2	393.8 Da LogP 3.26 TPSA 84.9	✓ Ro5	✓ Clean	`c1(c(c(c(c(c1Br)OO)Br)OO)Br)N`
BEF	4LDZ	O34723	66.0 Da LogP 0.88 TPSA 0.0	✓ Ro5	✓ Clean	`[Be-](F)(F)F`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

No virtual-screening candidates for this protein.

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA3879