Protein profile

PA3900

transmembrane sensor

Genome: NC_002516.2

Gene: PA3900 Structure source: AlphaFold UniProt Q9HXB3

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Amino acids 317

Annotations 1

Features 10

PDB binders 0

Druggability 0.57

Overview

Basic information about this protein and its source genome.

Accession: PA3900
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3900
Status: annotated
Amino acids: 317
Structure source: AlphaFold

GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.57

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

GO:0016989 The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
7	313	PANTHER	PTHR30273	PERIPLASMIC SIGNAL SENSOR AND SIGMA FACTOR ACTIVATOR FECR-RELATED
7	313	InterPro	IPR012373	Fe(2+)-dicitrate sensor, transmembrane component
101	233	FunFam	G3DSA:2.60.120.1440:FF:000002	Probable transmembrane sensor
4	316	PIRSF	PIRSF018266	FecR
4	316	InterPro	IPR012373	Fe(2+)-dicitrate sensor, transmembrane component
101	230	Gene3D	G3DSA:2.60.120.1440	-
113	204	Pfam	PF04773	FecR protein
113	204	InterPro	IPR006860	FecR protein
15	56	Pfam	PF16220	Domain of unknown function (DUF4880)
15	56	InterPro	IPR032623	FecR, N-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3900	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
8				0.57
1				0.324
5				0.211