Protein profile

PA3902

hypothetical protein

Genome: NC_002516.2

Gene: ivy PA3902 Structure source: Experimental + AlphaFold UniProt Q9HXB1
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Amino acids 153
Annotations 2
Features 14
PDB binders 0
Druggability 0.688

Overview

Basic information about this protein and its source genome.

Accession
PA3902
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
ivy PA3902
Status
annotated
Amino acids
153
Structure source
Experimental + AlphaFold
GO
GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0043086 Any process that stops or reduces the activity of an enzyme.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.688
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MNGVSRLLSLALLGAALHWAPAQAEEQPRLFELLGQPGYKATWHAMFKGESDVPKWVSDASGPSSPSTSLSLEGQPYVLANSCKPHDCGNNRLLVAFRGDKSAAYGLQVSLPDEPAEVMQTPSKYATYRWYGEPSRQVRELLMKQLESDPNWK

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0042597 The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
  • GO:0043086 Any process that stops or reduces the activity of an enzyme.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 24 SignalP_EUK SignalP-noTM SignalP-noTM
25 153 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
24 153 Gene3D G3DSA:3.40.1420.10 Inhibitor of vertebrate lysozyme
24 153 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
1 153 PIRSF PIRSF009103 Ivy
1 153 InterPro IPR014453 Inhibitor of vertebrate lysozyme
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
36 151 Pfam PF08816 Inhibitor of vertebrate lysozyme (Ivy)
1 24 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
25 153 SUPERFAMILY SSF89872 Inhibitor of vertebrate lysozyme, Ivy
25 153 InterPro IPR036501 Inhibitor of vertebrate lysozyme superfamily
7 17 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
18 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

2 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 4PS6
X-ray 1.25 Å A
84.3% 25-153
PDBe RCSB PDBj File
Viewing
PDB 1UUZ
X-ray 1.80 Å A,B
84.3% 25-153
PDBe RCSB PDBj File
Loaded
AlphaFold PA3902
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.688

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.22 0.111