Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3927
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3927
Status: annotated
Amino acids: 262
Structure source: AlphaFold

GO

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.924

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records

Show feature table

Start	End	DB	Term	Name
175	250	Pfam	PF12833	Helix-turn-helix domain
175	250	InterPro	IPR018060	DNA binding HTH domain, AraC-type
11	105	CDD	cd06124	cupin_NimR-like_N
203	244	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
203	244	InterPro	IPR018062	HTH domain AraC-type, conserved site
166	248	SMART	SM00342	aracneu4
166	248	InterPro	IPR018060	DNA binding HTH domain, AraC-type
5	253	PANTHER	PTHR11019	HTH-TYPE TRANSCRIPTIONAL REGULATOR NIMR
202	250	SUPERFAMILY	SSF46689	Homeodomain-like
202	250	InterPro	IPR009057	Homeobox-like domain superfamily
147	251	FunFam	G3DSA:1.10.10.60:FF:000132	AraC family transcriptional regulator
1	93	Gene3D	G3DSA:2.60.120.10	Jelly Rolls
1	93	InterPro	IPR014710	RmlC-like jelly roll fold
146	251	Gene3D	G3DSA:1.10.10.60	-
7	173	SUPERFAMILY	SSF51182	RmlC-like cupins
7	173	InterPro	IPR011051	RmlC-like cupin domain superfamily
150	250	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
150	250	InterPro	IPR018060	DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3927	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.924
2				0.641
3				0.458

PA3927