Protein profile

PA3934

hypothetical protein

Genome: NC_002516.2

Gene: PA3934 Structure source: Experimental + AlphaFold UniProt Q9HX82

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Amino acids 678

Annotations 2

Features 63

PDB binders 0

Druggability 0.735

Overview

Basic information about this protein and its source genome.

Accession: PA3934
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3934
Status: annotated
Amino acids: 678
Structure source: Experimental + AlphaFold

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0035673 Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.735

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MQERIPDELTLPELTLRGLILGALITVVFTASNVYLGLKVGLTFASSIPAAVISMAVLRYFSGANILENNMVQTQASAAGTLSSIIFILPGLLMIGYWSGFPFWQTAAICSIGGILGVLYTIPLRRVMVVQSELPYPEGVAAAEILRVGSDGAEDEEDARAPRAAGNAPGLYDILGGGLVAALFSLWSSGFKVLAEGFSVWLSAGQAAFRLSTGFSLALVGAGYLMGITAGIAILIGVVISWGVAVPLLTVNSVPADGQSLSDLATQLWSSQVRFLGAGTIGVAALWTLATLFKPMVRGVWASLGAVRGNSQANSLRTELDMPAKWILLIAGILLVSLFVVFSHFLGAAAPDMASPQFWSLVAVCVVFAFFFGFLIAAACGYMAGLVGSSSSPISGIGIIAVILVSLLILGFGSIEGGLLDRQNGKLAIALALFTTSVVLAIAAISNDNLQDLKTGYLVGATPWRQQVALIVGCIVGALVIPPVLELLYSAYGFTGALPREGMDPGQALAAPQATLMTAIASGIFHDALNWNMILIGVALGIALILVDLLLRRTGKACLPVLAVGLGIYLPPTIGMTLVVGALISWLLENALKKRAAAAGVDEEAYAEEPKRRGVLLASGLIVGESLMGILLAGVIGATGEDAPLALAGAGFAGIAQWLGLVVFVAICVLFYRRVLAR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0035673 Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.

Sequence Features

Domain/signature hits from InterPro and related databases.

63 records

Show feature table

Start	End	DB	Term	Name
226	231	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
383	393	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
207	225	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
103	122	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
527	532	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
326	346	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
170	187	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
232	251	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
63	73	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
448	467	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
640	644	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
206	225	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
275	293	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	31	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
416	426	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
188	206	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
533	551	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
650	672	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
123	169	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
615	637	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
615	639	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
468	490	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
509	526	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
14	36	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
42	62	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
529	551	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
563	588	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
74	97	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
76	98	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	636	NCBIfam	TIGR00733	oligopeptide transporter, OPT family
13	636	InterPro	IPR004814	Oligopeptide transporter OPT
256	274	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
427	447	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
566	588	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
425	447	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
393	415	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
490	508	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
169	191	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
673	678	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
37	41	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
271	293	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
98	102	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	13	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
41	63	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
13	634	Pfam	PF03169	OPT oligopeptide transporter protein
13	634	InterPro	IPR004813	Oligopeptide transporter, OPT superfamily
505	524	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
589	614	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
468	489	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
232	255	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
552	562	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
12	633	PANTHER	PTHR31645	OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED
12	633	InterPro	IPR045035	Metal-nicotianamine transporter YSL-like
102	124	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
394	415	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
645	672	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
294	325	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
358	382	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
326	348	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
7	632	NCBIfam	TIGR00728	OPT family oligopeptide transporter
7	632	InterPro	IPR004813	Oligopeptide transporter, OPT superfamily
358	380	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
347	357	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
PDB 6U3O	X-ray	2.74 Å	I,J	1.6% 129-139	PDBe RCSB PDBj File	Viewing
AlphaFold PA3934	AlphaFold	—	—	full sequence	—	Loaded

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.522
1				0.216