Protein profile

PA3935

taurine dioxygenase

Genome: NC_002516.2

Gene: tauD PA3935 Structure source: AlphaFold UniProt Q9HX81
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Amino acids 277
Annotations 5
Features 7
PDB binders 10
Druggability 0.295

Overview

Basic information about this protein and its source genome.

Accession
PA3935
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
tauD PA3935
Status
annotated
Amino acids
277
Structure source
AlphaFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872 Binding to a metal ion. GO:0000908 Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite. GO:0006790 The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.295
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0046872 Binding to a metal ion.
  • GO:0000908 Catalysis of the reaction: 2-oxoglutarate + O2 + taurine = aminoacetaldehyde + CO2 + succinate + sulfite.
  • GO:0006790 The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records
Show feature table
Start End DB Term Name
4 277 PANTHER PTHR30468 ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE
1 277 FunFam G3DSA:3.60.130.10:FF:000002 Alpha-ketoglutarate-dependent taurine dioxygenase
1 277 Gene3D G3DSA:3.60.130.10 -
1 277 InterPro IPR042098 Taurine dioxygenase TauD-like superfamily
5 270 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family
5 270 InterPro IPR003819 TauD/TfdA-like domain
3 277 SUPERFAMILY SSF51197 Clavaminate synthase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3935
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.295

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

60 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AKG
1GQW
P37610 146.1 Da LogP -0.50 TPSA 91.7 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)C(=O)O
C26
1OIK
Q9WWU5 210.3 Da LogP 2.02 TPSA 63.6 ✓ Ro5 ✓ Clean CCCC[C@@H](CC)COS(=O)(=O)O
CFA
6D3I
Q8KSC8 221.0 Da LogP 2.46 TPSA 46.5 ✓ Ro5 ✓ Clean c1cc(c(cc1Cl)Cl)OCC(=O)O
FTJ
6D3M
Q8KSC8 344.8 Da LogP 3.93 TPSA 81.5 ✓ Ro5 ✓ Clean C[C@H](C(=O)O)Oc1ccc(cc1)Oc2cnc3cc(ccc3n2)Cl
FTV
6D3H
Q8KSC8 235.1 Da LogP 2.85 TPSA 46.5 ✓ Ro5 ✓ Clean C[C@H](C(=O)O)Oc1ccc(cc1Cl)Cl
O0D
5BKC
P83310 328.2 Da LogP 4.03 TPSA 68.7 ✓ Ro5 ✓ Clean C[C@H](C(=O)O)Oc1ccc(cc1)Oc2c(cc(cn2)Cl)Cl
RCF
5BKD
P83310 301.3 Da LogP 3.34 TPSA 79.6 ✓ Ro5 ✓ Clean CC(C(=O)O)Oc1ccc(cc1)Oc2ccc(cc2F)C#N
SIN
5BK9
P83310 118.1 Da LogP -0.06 TPSA 74.6 ✓ Ro5 ✓ Clean C(CC(=O)O)C(=O)O
TAU
1GQW
P37610 125.1 Da LogP -1.17 TPSA 80.4 ✓ Ro5 ✓ Clean C(CS(=O)(=O)O)N
VVO
5BK9
P83310 66.9 Da LogP -0.12 TPSA 17.1 ✓ Ro5 ✓ Clean O=[V+2]

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.