Protein profile

PA3940

DNA binding protein

Genome: NC_002516.2

Gene: CAZ10_27010 hupN PA3940 GNQ48_15175 PAERUG_P19_London_7_VIM_2_05_10_00961 L4V69_08630 GUL26_00415 IPC1295_14340 ALP65_02839 Structure source: AlphaFold UniProt G3XCL3 UniProt Q9HX76
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Amino acids 93
Annotations 4
Features 17
PDB binders 0
Druggability 0.673

Overview

Basic information about this protein and its source genome.

Accession
PA3940
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
CAZ10_27010 hupN PA3940 GNQ48_15175 PAERUG_P19_London_7_VIM_2_05_10_00961 L4V69_08630 GUL26_00415 IPC1295_14340 ALP65_02839
Status
annotated
Amino acids
93
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin. GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.673
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MALTKDQLIQDIAEAIDAQKTTVRSALDQLAEIVKDALENDGEITLPGIGKLKVSERPARTGRNPQTGKAIEIAAKRVAKFVPAKALTDAING

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0030527 The action of a molecule that contributes to the structural integrity of chromatin.
  • GO:0030261 The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
42 57 PRINTS PR01727 Prokaryotic integration host factor signature
42 57 InterPro IPR000119 Histone-like DNA-binding protein
60 73 PRINTS PR01727 Prokaryotic integration host factor signature
60 73 InterPro IPR000119 Histone-like DNA-binding protein
76 90 PRINTS PR01727 Prokaryotic integration host factor signature
76 90 InterPro IPR000119 Histone-like DNA-binding protein
3 92 Pfam PF00216 Bacterial DNA-binding protein
3 92 InterPro IPR000119 Histone-like DNA-binding protein
5 89 CDD cd00591 HU_IHF
1 91 PANTHER PTHR33175 DNA-BINDING PROTEIN HU
1 91 InterPro IPR000119 Histone-like DNA-binding protein
1 92 FunFam G3DSA:4.10.520.10:FF:000013 Probable DNA binding protein
1 92 Gene3D G3DSA:4.10.520.10 -
1 92 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
3 92 SUPERFAMILY SSF47729 IHF-like DNA-binding proteins
3 92 InterPro IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily
3 92 SMART SM00411 bhlneu

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA3940
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.673