Protein profile

PA3967

hypothetical protein

Genome: NC_002516.2

Gene: PA3967 Structure source: Experimental + AlphaFold UniProt Q9HX49
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Amino acids 130
Annotations 4
Features 8
PDB binders 1
Druggability 0.906

Overview

Basic information about this protein and its source genome.

Accession
PA3967
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA3967
Status
annotated
Amino acids
130
Structure source
Experimental + AlphaFold
GO
GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. GO:0046872 Binding to a metal ion. GO:0019825 Binding to oxygen (O2). GO:0005344 Binding to oxygen and delivering it to an acceptor molecule or a specific location.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.906
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0020037 Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
  • GO:0046872 Binding to a metal ion.
  • GO:0019825 Binding to oxygen (O2).
  • GO:0005344 Binding to oxygen and delivering it to an acceptor molecule or a specific location.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
1 130 Gene3D G3DSA:1.10.490.10 Globins
1 130 InterPro IPR012292 Globin/Protoglobin
23 121 Pfam PF00042 Globin
23 121 InterPro IPR000971 Globin
7 126 CDD cd01040 Mb-like
7 126 InterPro IPR044399 Myoglobin-like, M family globin domain
5 130 SUPERFAMILY SSF46458 Globin-like
5 130 InterPro IPR009050 Globin-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 1TU9
X-ray 1.20 Å A
100.0% 1-130
PDBe RCSB PDBj File
Viewing
AlphaFold PA3967
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.906
2 0.302

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 43.63 0.97
2 1.35 0.016

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

1 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
PPI
1TU9 1.20 Å Open crystal
74.1 Da LogP 0.48 TPSA 37.3 ✓ Ro5 ✓ Clean CCC(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.