Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA3982
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA3982 ybeY
Status: annotated
Amino acids: 160
Structure source: AlphaFold

EC

3.1.-.-

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks. GO:0008270 Binding to a zinc ion (Zn). GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.875

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

3.1.-.-

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.
GO:0008270 Binding to a zinc ion (Zn).
GO:0006364 Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
10	152	PANTHER	PTHR46986	ENDORIBONUCLEASE YBEY, CHLOROPLASTIC
10	152	InterPro	IPR002036	Endoribonuclease YbeY
5	148	SUPERFAMILY	SSF55486	Metalloproteases ("zincins"), catalytic domain
4	146	Hamap	MF_00009	Endoribonuclease YbeY [ybeY].
4	146	InterPro	IPR002036	Endoribonuclease YbeY
15	145	NCBIfam	TIGR00043	rRNA maturation RNase YbeY
15	145	InterPro	IPR002036	Endoribonuclease YbeY
19	142	Pfam	PF02130	Endoribonuclease YbeY
19	142	InterPro	IPR002036	Endoribonuclease YbeY
112	122	ProSitePatterns	PS01306	Uncharacterized protein family UPF0054 signature.
112	122	InterPro	IPR020549	Endoribonuclease YbeY, conserved site
2	153	Gene3D	G3DSA:3.40.390.30	Metalloproteases ("zincins"), catalytic domain
2	153	InterPro	IPR023091	Metalloprotease catalytic domain superfamily, predicted
138	160	MobiDBLite	mobidb-lite	consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA3982	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
6				0.875
5				0.679

PA3982