Amino acids
207
Annotations
6
Features
21
PDB binders
0
Overview
Basic information about this protein and its source genome.
- Accession
- PA3988
- Gene
- lptE PA3988
- Status
- annotated
- Amino acids
- 207
- Structure source
- Experimental + AlphaFold
GO
GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:1990351 A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.
GO:0001530 Binding to a lipopolysaccharide.
GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0015920 The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
Target profile
Computed evidence for target prioritization.
- Human off-target
- No hit
- Gut microbiome off-target
- hit
- Essential (DEG)
- Y
- Localization
- Unknown
Sequence
Primary amino-acid sequence viewer.
Functional Annotations
Enzyme classification and Gene Ontology terms linked to this protein.
6 GO
Gene Ontology (GO)
6- GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
- GO:1990351 A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells.
- GO:0001530 Binding to a lipopolysaccharide.
- GO:0043165 The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.
- GO:0015920 The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
- GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
Sequence Features
Domain/signature hits from InterPro and related databases.
21 records
Show feature table
| Start | End | DB | Term | Name |
|---|---|---|---|---|
| 1 | 20 | ProSiteProfiles | PS51257 | Prokaryotic membrane lipoprotein lipid attachment site profile. |
| 1 | 18 | SignalP_GRAM_NEGATIVE | SignalP-noTM | SignalP-noTM |
| 19 | 207 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. |
| 1 | 19 | SignalP_EUK | SignalP-noTM | SignalP-noTM |
| 164 | 194 | Coils | Coil | Coil |
| 1 | 18 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM |
| 166 | 207 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 35 | 155 | Pfam | PF04390 | Lipopolysaccharide-assembly |
| 35 | 155 | InterPro | IPR007485 | LPS-assembly lipoprotein LptE |
| 4 | 11 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. |
| 1 | 3 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. |
| 12 | 18 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. |
| 18 | 183 | Gene3D | G3DSA:3.30.160.150 | Lipoprotein like domain |
| 1 | 193 | PANTHER | PTHR38098 | LPS-ASSEMBLY LIPOPROTEIN LPTE |
| 1 | 193 | InterPro | IPR007485 | LPS-assembly lipoprotein LptE |
| 1 | 18 | Phobius | SIGNAL_PEPTIDE | Signal peptide region |
| 5 | 27 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. |
| 169 | 196 | MobiDBLite | mobidb-lite | consensus disorder prediction |
| 18 | 183 | FunFam | G3DSA:3.30.160.150:FF:000003 | LPS-assembly lipoprotein LptE |
| 5 | 161 | Hamap | MF_01186 | LPS-assembly lipoprotein LptE [lptE]. |
| 5 | 161 | InterPro | IPR007485 | LPS-assembly lipoprotein LptE |
3D Structure
Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.
No pockets are loaded yet for the displayed PDB 5IVA structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.
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Structural evidence
3 + 1Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.