Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4005
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: rsfS PA4005
Status: annotated
Amino acids: 118
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0043023 Binding to a large ribosomal subunit. GO:0042256 The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol. GO:0090071 Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits. GO:0017148 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 32.759
Human E-value: 3.94e-15
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0043023 Binding to a large ribosomal subunit.
GO:0042256 The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional cytosolic ribosome. Distinct stages of this process take place first in the nucleolus, then in the nucleus and finally in the cytosol.
GO:0090071 Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.
GO:0017148 Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
1	111	SUPERFAMILY	SSF81301	Nucleotidyltransferase
1	111	InterPro	IPR043519	Nucleotidyltransferase superfamily
1	116	Gene3D	G3DSA:3.30.460.10	Beta Polymerase, domain 2
1	116	InterPro	IPR043519	Nucleotidyltransferase superfamily
10	104	Pfam	PF02410	Ribosomal silencing factor during starvation
7	104	NCBIfam	TIGR00090	ribosome silencing factor
7	104	InterPro	IPR004394	Protein Iojap/ribosomal silencing factor RsfS
8	116	PANTHER	PTHR21043	IOJAP SUPERFAMILY ORTHOLOG
8	116	InterPro	IPR004394	Protein Iojap/ribosomal silencing factor RsfS
3	105	Hamap	MF_01477	Ribosomal silencing factor RsfS [rsfS].
3	105	InterPro	IPR004394	Protein Iojap/ribosomal silencing factor RsfS

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model PA4005 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

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Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4005	AlphaFold	—	—	full sequence	—	Viewing