Protein profile

PA4007

gamma-glutamyl phosphate reductase

Genome: NC_002516.2

Gene: proA PA4007 Structure source: AlphaFold UniProt Q9HX20
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Amino acids 421
Annotations 8
Features 23
PDB binders 0
Druggability 0.801

Overview

Basic information about this protein and its source genome.

Accession
PA4007
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
proA PA4007
Status
annotated
Amino acids
421
Structure source
AlphaFold
EC
1.2.1.41
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004350 Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH. GO:0050661 Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0055129 The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
38.835
Human E-value
2.78e-84
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.801
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 7 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

7
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0004350 Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP+ + phosphate = L-glutamyl 5-phosphate + H+ + NADPH.
  • GO:0050661 Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
  • GO:0055129 The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
  • GO:0016491 Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
  • GO:0016620 Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
  • GO:0006561 OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
327 349 ProSitePatterns PS01223 Gamma-glutamyl phosphate reductase signature.
327 349 InterPro IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site
229 378 FunFam G3DSA:3.40.309.10:FF:000006 Gamma-glutamyl phosphate reductase
16 410 NCBIfam TIGR00407 glutamate-5-semialdehyde dehydrogenase
16 410 InterPro IPR000965 GPR domain
313 377 Pfam PF00171 Aldehyde dehydrogenase family
313 377 InterPro IPR015590 Aldehyde dehydrogenase domain
14 283 Pfam PF00171 Aldehyde dehydrogenase family
14 283 InterPro IPR015590 Aldehyde dehydrogenase domain
8 420 Hamap MF_00412 Gamma-glutamyl phosphate reductase [proA].
8 420 InterPro IPR000965 GPR domain
15 417 Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A, domain 1
15 417 InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
229 378 Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A, domain 2
229 378 InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
35 55 Coils Coil Coil
8 420 SUPERFAMILY SSF53720 ALDH-like
8 420 InterPro IPR016161 Aldehyde/histidinol dehydrogenase
5 420 PANTHER PTHR11063 GLUTAMATE SEMIALDEHYDE DEHYDROGENASE
1 421 PIRSF PIRSF000151 GPR
1 421 InterPro IPR012134 Glutamate-5-semialdehyde dehydrogenase
52 416 CDD cd07079 ALDH_F18-19_ProA-GPR
52 416 InterPro IPR000965 GPR domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4007
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.801
6 0.477