Protein profile

PA4012

hypothetical protein

Genome: NC_002516.2

Gene: PA4012 Structure source: AlphaFold UniProt Q9HX15
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Amino acids 197
Annotations 0
Features 16
PDB binders 0
Druggability 0.896

Overview

Basic information about this protein and its source genome.

Accession
PA4012
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4012
Status
annotated
Amino acids
197
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
34.127
Human E-value
6.56e-09
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.896
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
2 188 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain
2 188 InterPro IPR003111 Lon protease, N-terminal domain
2 192 SMART SM00464 lon_5
2 192 InterPro IPR003111 Lon protease, N-terminal domain
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
19 197 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
14 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 188 SUPERFAMILY SSF88697 PUA domain-like
1 188 InterPro IPR015947 PUA-like superfamily
1 111 Gene3D G3DSA:2.30.130.40 -
1 111 InterPro IPR046336 Lon protease, N-terminal domain superfamily
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
3 189 ProSiteProfiles PS51787 Lon N-terminal domain profile.
3 189 InterPro IPR003111 Lon protease, N-terminal domain
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 129 PANTHER PTHR46732 ATP-DEPENDENT PROTEASE LA (LON) DOMAIN PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4012
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.896
3 0.604
4 0.377