Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4025
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4025 eutC
Status: annotated
Amino acids: 273
Structure source: AlphaFold

EC

4.3.1.7

GO

GO:0009350 An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. GO:0031471 An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase. GO:0031419 Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. GO:0008851 Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.513

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

4.3.1.7

Gene Ontology (GO)

6

GO:0009350 An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia.
GO:0031471 An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.
GO:0031419 Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
GO:0008851 Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+.
GO:0006520 The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
GO:0046336 The chemical reactions and pathways resulting in the breakdown of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
67	251	Gene3D	G3DSA:3.40.50.11240	-
67	251	InterPro	IPR042251	Ethanolamine ammonia-lyase light chain, C-terminal
6	251	PANTHER	PTHR39330	ETHANOLAMINE AMMONIA-LYASE LIGHT CHAIN
6	251	InterPro	IPR009246	Ethanolamine ammonia-lyase small subunit
1	261	PIRSF	PIRSF018982	EutC
1	261	InterPro	IPR009246	Ethanolamine ammonia-lyase small subunit
2	56	Gene3D	G3DSA:1.10.30.40	-
2	56	InterPro	IPR042255	Ethanolamine ammonia-lyase light chain, N-terminal
11	252	Hamap	MF_00601	Ethanolamine ammonia-lyase small subunit [eutC].
11	252	InterPro	IPR009246	Ethanolamine ammonia-lyase small subunit
66	251	FunFam	G3DSA:3.40.50.11240:FF:000001	Ethanolamine ammonia-lyase light chain
1	57	FunFam	G3DSA:1.10.30.40:FF:000001	Ethanolamine ammonia-lyase light chain
13	250	Pfam	PF05985	Ethanolamine ammonia-lyase light chain (EutC)
13	250	InterPro	IPR009246	Ethanolamine ammonia-lyase small subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4025	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.513

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

3 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

No PDB structure with a co-crystallized ligand found for this exact protein.

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Ligand	Source crystal	UniProt (homolog)	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ETA	3ABO	P19636	61.1 Da LogP -1.06 TPSA 46.2	✓ Ro5	✓ Clean	`C(CO)N`

Experimental bioactivity from ChEMBL measured directly on this protein. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL bioactivity data found for this exact protein.

Bioactivity inferred from similar proteins in ChEMBL. Score = pchembl (−log Ki/IC₅₀; higher = more potent).

No ChEMBL hits found through similar proteins.

Proposed virtual-screening candidates from ZINC. Score = Tanimoto similarity to a known binder (0–1; higher = more similar).

Ligand	Tanimoto	MW · LogP · TPSA	Lipinski	PAINS	SMILES
ZINC2385445	0.500	201.4 Da LogP 2.84 TPSA 46.2	✓ Ro5	✓ Clean	`NCCCCCCCCCCCCO`
ZINC34196183	0.500	229.4 Da LogP 3.62 TPSA 46.2	✓ Ro5	✓ Clean	`NCCCCCCCCCCCCCCO`

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.

PA4025