Protein profile

PA4030

hypothetical protein

Genome: NC_002516.2

Gene: PA4030 Structure source: AlphaFold UniProt Q9HWZ7

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Amino acids 276

Annotations 3

Features 12

PDB binders 0

Druggability 0.738

Overview

Basic information about this protein and its source genome.

Accession: PA4030
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4030
Status: annotated
Amino acids: 276
Structure source: AlphaFold

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004177 Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.738

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MWSFRAWRRRRLLARHPVAEELWQRVRRHLPILDGLDADEDRRLRERAVLFLADKHLTALAGVDLDDFGRLLLAAQAQLPLLHLPELNWYQGFHELVLYPDDFVSPQKHRDASGVVHEFDDERSGETSLQGPVVLAWPGVVGGGGWDAYNLVIHELAHKLDMLNGDANGLPPLHAGMRIGDWASAMQAAYDEMNALLDRDPDAQTAIDPYAAEDPAEFFAVTSEYFFTAPDLLHEAYPAVYRQLQLFYRQDPLQRLRRLQAEHPDYREAAGDTTNG

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0004177 Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain.
GO:0008237 Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records

Show feature table

Start	End	DB	Term	Name
19	141	Gene3D	G3DSA:1.10.472.150	-
19	141	InterPro	IPR042252	MtfA, N-terminal
40	248	CDD	cd20169	Peptidase_M90_mtfA
40	248	InterPro	IPR010384	MtfA family
146	268	FunFam	G3DSA:3.40.390.10:FF:000012	Protein MtfA
147	269	Gene3D	G3DSA:3.40.390.10	Collagenase (Catalytic Domain)
147	269	InterPro	IPR024079	Metallopeptidase, catalytic domain superfamily
6	265	PANTHER	PTHR30164	MTFA PEPTIDASE
6	265	InterPro	IPR010384	MtfA family
39	251	SUPERFAMILY	SSF55486	Metalloproteases ("zincins"), catalytic domain
5	249	Pfam	PF06167	Glucose-regulated metallo-peptidase M90
5	249	InterPro	IPR010384	MtfA family

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4030	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.738