Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4042
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4042 xseB
Status: annotated
Amino acids: 80
Structure source: AlphaFold

EC

3.1.11.6

GO

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0009318 An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA. GO:0008855 Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides. GO:0006308 The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.789

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

3.1.11.6

Gene Ontology (GO)

4

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0009318 An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA.
GO:0008855 Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides.
GO:0006308 The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records

Show feature table

Start	End	DB	Term	Name
9	60	Pfam	PF02609	Exonuclease VII small subunit
9	60	InterPro	IPR003761	Exonuclease VII, small subunit
8	63	NCBIfam	TIGR01280	exodeoxyribonuclease VII small subunit
8	63	InterPro	IPR003761	Exonuclease VII, small subunit
2	79	FunFam	G3DSA:1.10.287.1040:FF:000011	Exodeoxyribonuclease 7 small subunit
2	76	PANTHER	PTHR34137	EXODEOXYRIBONUCLEASE 7 SMALL SUBUNIT
2	76	InterPro	IPR003761	Exonuclease VII, small subunit
2	79	Gene3D	G3DSA:1.10.287.1040	Exonuclease VII, small subunit
2	79	InterPro	IPR037004	Exonuclease VII, small subunit superfamily
1	80	PIRSF	PIRSF006488	ExoVII_small
1	80	InterPro	IPR003761	Exonuclease VII, small subunit
3	68	SUPERFAMILY	SSF116842	XseB-like
3	68	InterPro	IPR037004	Exonuclease VII, small subunit superfamily
8	68	Hamap	MF_00337	Exodeoxyribonuclease 7 small subunit [xseB].
8	68	InterPro	IPR003761	Exonuclease VII, small subunit

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4042	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.789
2				0.382
3				0.38

PA4042