Protein profile

PA4048

hypothetical protein

Genome: NC_002516.2

Gene: PA4048 Structure source: AlphaFold UniProt Q9HWY0
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Amino acids 214
Annotations 2
Features 18
PDB binders 0
Druggability 0.778

Overview

Basic information about this protein and its source genome.

Accession
PA4048
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4048
Status
annotated
Amino acids
214
Structure source
AlphaFold
GO
GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.778
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0004190 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
102 197 CDD cd05483 retropepsin_like_bacteria
102 197 InterPro IPR034122 Retropepsin-like domain, bacterial
87 214 Gene3D G3DSA:2.40.70.10 Acid Proteases
87 214 InterPro IPR021109 Aspartic peptidase domain superfamily
1 19 SignalP_EUK SignalP-TM SignalP-TM
117 128 ProSitePatterns PS00141 Eukaryotic and viral aspartyl proteases active site.
117 128 InterPro IPR001969 Aspartic peptidase, active site
1 19 Phobius SIGNAL_PEPTIDE Signal peptide region
94 211 NCBIfam TIGR02281 TIGR02281 family clan AA aspartic protease
94 211 InterPro IPR011969 Clan AA aspartic peptidase, C-terminal
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
98 201 SUPERFAMILY SSF50630 Acid proteases
98 201 InterPro IPR021109 Aspartic peptidase domain superfamily
107 198 Pfam PF13975 gag-polyprotein putative aspartyl protease
16 19 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
20 214 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 15 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4048
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.778
2 0.615