Protein profile

PA4052

transcription antitermination protein NusB

Genome: NC_002516.2

Gene: nusB PA4052 Structure source: AlphaFold UniProt Q9HWX6
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Amino acids 159
Annotations 5
Features 15
PDB binders 1
Druggability 0.903

Overview

Basic information about this protein and its source genome.

Accession
PA4052
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nusB PA4052
Status
annotated
Amino acids
159
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0006353 The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. GO:0031564 A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.903
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0006353 The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template.
  • GO:0031564 A positive regulation of gene expression mechanism that allows RNA polymerase to continue transcription beyond a termination site, thus allowing expression of downstream genes under specific conditions.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
19 150 SUPERFAMILY SSF48013 NusB-like
19 150 InterPro IPR035926 NusB-like superfamily
61 148 PANTHER PTHR11078 N UTILIZATION SUBSTANCE PROTEIN B-RELATED
61 148 InterPro IPR011605 NusB antitermination factor
22 146 Pfam PF01029 NusB family
22 146 InterPro IPR006027 NusB/RsmB/TIM44
16 153 Gene3D G3DSA:1.10.940.10 -
16 153 InterPro IPR035926 NusB-like superfamily
1 21 MobiDBLite mobidb-lite consensus disorder prediction
21 147 NCBIfam TIGR01951 transcription antitermination factor NusB
21 147 InterPro IPR011605 NusB antitermination factor
19 150 Hamap MF_00073 Transcription antitermination protein NusB [nusB].
19 150 InterPro IPR011605 NusB antitermination factor
21 147 CDD cd00619 Terminator_NusB
16 153 FunFam G3DSA:1.10.940.10:FF:000001 Transcription antitermination factor NusB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4052
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.903
3 0.239

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

33 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
NHE
3D3B
P0A780 207.3 Da LogP 0.80 TPSA 66.4 ✓ Ro5 ✓ Clean C1CCC(CC1)NCCS(=O)(=O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.