Protein profile

PA4057

transcriptional regulator NrdR

Genome: NC_002516.2

Gene: nrdR PA4057 Structure source: AlphaFold UniProt Q9HWX1
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Amino acids 154
Annotations 4
Features 10
PDB binders 0
Druggability 0.799

Overview

Basic information about this protein and its source genome.

Accession
PA4057
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
nrdR PA4057
Status
annotated
Amino acids
154
Structure source
AlphaFold
GO
GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003690 Binding to double-stranded DNA. GO:0008270 Binding to a zinc ion (Zn). GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.799
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005524 Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
  • GO:0003690 Binding to double-stranded DNA.
  • GO:0008270 Binding to a zinc ion (Zn).
  • GO:0045892 Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 153 Hamap MF_00440 Transcriptional repressor NrdR [nrdR].
1 153 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like
1 147 NCBIfam TIGR00244 transcriptional regulator NrdR
1 147 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like
49 139 ProSiteProfiles PS51161 ATP-cone domain profile.
49 139 InterPro IPR005144 ATP-cone domain
52 136 Pfam PF03477 ATP cone domain
52 136 InterPro IPR005144 ATP-cone domain
1 151 PANTHER PTHR30455 TRANSCRIPTIONAL REPRESSOR NRDR
1 151 InterPro IPR003796 Ribonucleotide reductase regulator NrdR-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4057
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.799