Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4065
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4065
Status: annotated
Amino acids: 421
Structure source: AlphaFold

GO

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.959

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

21 records

Show feature table

Start	End	DB	Term	Name
293	315	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	34	Phobius	SIGNAL_PEPTIDE	Signal peptide region
1	419	PANTHER	PTHR43738	ABC TRANSPORTER, MEMBRANE PROTEIN
1	15	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
336	358	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	30	ProSiteProfiles	PS51257	Prokaryotic membrane lipoprotein lipid attachment site profile.
19	260	Pfam	PF12704	MacB-like periplasmic core domain
19	260	InterPro	IPR025857	MacB-like periplasmic core domain
336	362	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
28	34	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
294	412	Pfam	PF02687	FtsX-like permease family
294	412	InterPro	IPR003838	ABC3 transporter permease protein domain
291	315	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
363	386	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
387	409	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
16	35	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
387	406	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
316	335	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
16	27	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
35	290	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
407	421	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4065	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
18				0.895
11				0.746
6				0.609
9				0.538

PA4065