Protein profile

PA4066

hypothetical protein

Genome: NC_002516.2

Gene: PA4066 Structure source: Experimental + AlphaFold UniProt Q9HWW2

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Amino acids 172

Annotations 0

Features 10

PDB binders 0

Druggability 0.876

Overview

Basic information about this protein and its source genome.

Accession: PA4066
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4066
Status: annotated
Amino acids: 172
Structure source: Experimental + AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.876

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
23	172	Gene3D	G3DSA:2.40.50.870	Protein of unknown function (DUF3299)
1	23	Phobius	SIGNAL_PEPTIDE	Signal peptide region
24	172	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1	23	SignalP_GRAM_POSITIVE	SignalP-TM	SignalP-TM
17	23	Phobius	SIGNAL_PEPTIDE_C_REGION	C-terminal region of a signal peptide.
5	16	Phobius	SIGNAL_PEPTIDE_H_REGION	Hydrophobic region of a signal peptide.
30	165	Pfam	PF11736	Protein of unknown function (DUF3299)
30	165	InterPro	IPR021727	Protein of unknown function DUF3299
1	4	Phobius	SIGNAL_PEPTIDE_N_REGION	N-terminal region of a signal peptide.
1	23	SignalP_EUK	SignalP-noTM	SignalP-noTM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
PDB 4HSP	X-ray	2.45 Å	A	86.6% 24-172	PDBe RCSB PDBj File	Viewing
AlphaFold PA4066	AlphaFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.876
3				0.581

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.842