Protein profile

PA4067

outer membrane protein OprG

Genome: NC_002516.2

Gene: PA4067 oprG Structure source: Experimental + AlphaFold UniProt Q9HWW1
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Amino acids 232
Annotations 4
Features 16
PDB binders 2
Druggability 0.975

Overview

Basic information about this protein and its source genome.

Accession
PA4067
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4067 oprG
Status
annotated
Amino acids
232
Structure source
Experimental + AlphaFold
GO
GO:0044384 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.975
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0044384 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell.
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 232 PANTHER PTHR36920 -
1 232 InterPro IPR005618 Outer membrane protein, OmpW
5 16 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
28 232 Pfam PF03922 OmpW family
28 232 InterPro IPR005618 Outer membrane protein, OmpW
1 21 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
23 232 Gene3D G3DSA:2.40.160.20 -
17 21 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
28 232 SUPERFAMILY SSF56925 OMPA-like
28 232 InterPro IPR011250 Outer membrane protein/outer membrane enzyme PagP, beta-barrel
1 21 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 21 Phobius SIGNAL_PEPTIDE Signal peptide region
1 4 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
22 232 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
224 232 ProSitePatterns PS00695 Enterobacterial virulence outer membrane protein signature 2.
224 232 InterPro IPR000758 Virulence-related outer membrane protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2X27
X-ray 2.40 Å X
90.5% 23-232
PDBe RCSB PDBj File
Viewing
AlphaFold PA4067
AlphaFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.975
2 0.278
5 0.233

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.55 0.331
2 4.55 0.195
3 2.96 0.096

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

52 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
C8E
2X27 2.40 Å Open crystal
306.4 Da LogP 2.41 TPSA 57.2 ✓ Ro5 ✓ Clean CCCCCCCCOCCOCCOCCOCCO

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.