Protein profile

PA4074

transcriptional regulator

Genome: NC_002516.2

Gene: PA4074 Structure source: AlphaFold UniProt Q9HWV4
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Amino acids 222
Annotations 2
Features 19
PDB binders 0
Druggability 0.927

Overview

Basic information about this protein and its source genome.

Accession
PA4074
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4074
Status
annotated
Amino acids
222
Structure source
AlphaFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.927
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
141 220 Gene3D G3DSA:1.10.10.10 -
141 220 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
166 180 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
166 180 InterPro IPR000792 Transcription regulator LuxR, C-terminal
196 208 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
196 208 InterPro IPR000792 Transcription regulator LuxR, C-terminal
180 196 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature
180 196 InterPro IPR000792 Transcription regulator LuxR, C-terminal
165 218 Pfam PF00196 Bacterial regulatory proteins, luxR family
165 218 InterPro IPR000792 Transcription regulator LuxR, C-terminal
163 220 SMART SM00421 luxrmega5
163 220 InterPro IPR000792 Transcription regulator LuxR, C-terminal
63 219 PANTHER PTHR44688 -
159 222 ProSiteProfiles PS50043 LuxR-type HTH domain profile.
159 222 InterPro IPR000792 Transcription regulator LuxR, C-terminal
166 222 CDD cd06170 LuxR_C_like
166 222 InterPro IPR000792 Transcription regulator LuxR, C-terminal
149 219 SUPERFAMILY SSF46894 C-terminal effector domain of the bipartite response regulators
149 219 InterPro IPR016032 Signal transduction response regulator, C-terminal effector

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4074
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.927