Protein profile

PA4081

fimbrial subunit CupB6

Genome: NC_002516.2

Gene: PA4081 cupB6 Structure source: Experimental + AlphaFold UniProt Q9HWU7
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Amino acids 381
Annotations 3
Features 14
PDB binders 0
Druggability 0.832

Overview

Basic information about this protein and its source genome.

Accession
PA4081
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4081 cupB6
Status
annotated
Amino acids
381
Structure source
Experimental + AlphaFold
GO
GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.832
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 38 Phobius SIGNAL_PEPTIDE Signal peptide region
1 22 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
34 38 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
241 380 Gene3D G3DSA:2.60.40.1090 -
241 380 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
39 381 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
90 381 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
23 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
242 380 SUPERFAMILY SSF49401 Bacterial adhesins
242 380 InterPro IPR008966 Adhesion domain superfamily
241 380 Pfam PF00419 Fimbrial protein
241 380 InterPro IPR000259 Fimbrial-type adhesion domain
1 38 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 38 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5CYL
X-ray 2.77 Å A,B,C,D,E,F,G,H
90.3% 38-381
PDBe RCSB PDBj File
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AlphaFold PA4081
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