Protein profile

PA4082

adhesive protein CupB5

Genome: NC_002516.2

Gene: PA4082 cupB5 Structure source: AlphaFold UniProt Q9HWU6
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Amino acids 1018
Annotations 1
Features 24
PDB binders 0
Druggability 0.443

Overview

Basic information about this protein and its source genome.

Accession
PA4082
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4082 cupB5
Status
annotated
Amino acids
1018
Structure source
AlphaFold
GO
GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.443
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005576 The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
506 689 Gene3D G3DSA:2.160.20.110 -
853 1006 Gene3D G3DSA:2.160.20.110 -
1 15 ProSiteProfiles PS51257 Prokaryotic membrane lipoprotein lipid attachment site profile.
1 33 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
591 784 PANTHER PTHR12338 AUTOTRANSPORTER
88 162 NCBIfam TIGR01901 filamentous hemagglutinin family N-terminal domain
88 162 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain
55 305 Pfam PF05860 TPS secretion domain
55 305 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain
718 741 Pfam PF07581 The GLUG motif
718 741 InterPro IPR011493 GLUG
647 677 Pfam PF07581 The GLUG motif
647 677 InterPro IPR011493 GLUG
55 1018 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 56 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
51 166 SMART SM00912 Haemagg_act_2a
51 166 InterPro IPR008638 Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain
54 411 Gene3D G3DSA:2.160.20.10 -
54 411 InterPro IPR012334 Pectin lyase fold
45 343 SUPERFAMILY SSF51126 Pectin lyase-like
45 343 InterPro IPR011050 Pectin lyase fold/virulence factor
34 54 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 49 Pfam PF13018 Extended Signal Peptide of Type V secretion system
1 49 InterPro IPR024973 ESPR domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4082
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.443