Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4084
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4084 cupB3
Status: annotated
Amino acids: 844
Structure source: AlphaFold

GO

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone. GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005515 Binding to a protein.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: OuterMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.331

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0009279 A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
GO:0015473 A porin that acts in the assembly of fimbria together with fimbrial chaperone.
GO:0009297 The assembly from its constituent parts of a pilus, a short filamentous structure of bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0005515 Binding to a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
754	819	Pfam	PF13953	PapC C-terminal domain
754	819	InterPro	IPR025949	PapC-like, C-terminal domain
609	623	MobiDBLite	mobidb-lite	consensus disorder prediction
19	172	Pfam	PF13954	PapC N-terminal domain
19	172	InterPro	IPR025885	PapC, N-terminal domain
661	749	Gene3D	G3DSA:2.60.40.2610	Outer membrane usher protein FimD, plug domain
661	749	InterPro	IPR042186	Outer membrane usher protein FimD, plug domain
607	627	MobiDBLite	mobidb-lite	consensus disorder prediction
11	831	PANTHER	PTHR30451	OUTER MEMBRANE USHER PROTEIN
11	831	InterPro	IPR000015	Outer membrane usher protein
17	145	SUPERFAMILY	SSF141729	FimD N-terminal domain-like
17	145	InterPro	IPR037224	PapC, N-terminal domain superfamily
257	346	Gene3D	G3DSA:2.60.40.3110	-
753	841	Gene3D	G3DSA:2.60.40.2070	-
753	841	InterPro	IPR043142	PapC-like, C-terminal domain superfamily
257	346	FunFam	G3DSA:2.60.40.3110:FF:000001	Putative fimbrial outer membrane usher
17	147	Gene3D	G3DSA:3.10.20.410	-
17	147	InterPro	IPR037224	PapC, N-terminal domain superfamily
187	743	Pfam	PF00577	Outer membrane usher protein
187	743	InterPro	IPR000015	Outer membrane usher protein

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4084	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.331
13				0.297

PA4084