Protein profile

PA4086

fimbrial subunit CupB1

Genome: NC_002516.2

Gene: PA4086 cupB1 Structure source: AlphaFold UniProt Q9HWU2
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Amino acids 189
Annotations 3
Features 15
PDB binders 0
Druggability 0.804

Overview

Basic information about this protein and its source genome.

Accession
PA4086
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4086 cupB1
Status
annotated
Amino acids
189
Structure source
AlphaFold
GO
GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species. GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Extracellular

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.804
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0009289 A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter.
  • GO:0043709 The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
  • GO:0007155 The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
29 189 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 28 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
33 189 SUPERFAMILY SSF49401 Bacterial adhesins
33 189 InterPro IPR008966 Adhesion domain superfamily
1 28 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
1 28 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
3 189 PANTHER PTHR33420 FIMBRIAL SUBUNIT ELFA-RELATED
33 177 Pfam PF00419 Fimbrial protein
33 177 InterPro IPR000259 Fimbrial-type adhesion domain
1 28 Phobius SIGNAL_PEPTIDE Signal peptide region
33 188 Gene3D G3DSA:2.60.40.1090 -
33 188 InterPro IPR036937 Fimbrial-type adhesion domain superfamily
7 20 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4086
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.804
2 0.735