Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4094
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4094
Status: annotated
Amino acids: 319
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.857

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0000987 Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0009893 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

20 records

Show feature table

Start	End	DB	Term	Name
232	317	SMART	SM00342	aracneu4
232	317	InterPro	IPR018060	DNA binding HTH domain, AraC-type
5	319	PANTHER	PTHR46796	HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
267	318	SUPERFAMILY	SSF46689	Homeodomain-like
267	318	InterPro	IPR009057	Homeobox-like domain superfamily
211	319	Gene3D	G3DSA:1.10.10.60	-
301	317	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
301	317	InterPro	IPR020449	Transcription regulator HTH, AraC- type
286	301	PRINTS	PR00032	AraC bacterial regulatory protein HTH signature
286	301	InterPro	IPR020449	Transcription regulator HTH, AraC- type
216	265	SUPERFAMILY	SSF46689	Homeodomain-like
216	265	InterPro	IPR009057	Homeobox-like domain superfamily
238	319	Pfam	PF12833	Helix-turn-helix domain
238	319	InterPro	IPR018060	DNA binding HTH domain, AraC-type
218	319	ProSiteProfiles	PS01124	Bacterial regulatory proteins, araC family DNA-binding domain profile.
218	319	InterPro	IPR018060	DNA binding HTH domain, AraC-type
268	313	ProSitePatterns	PS00041	Bacterial regulatory proteins, araC family signature.
268	313	InterPro	IPR018062	HTH domain AraC-type, conserved site
26	198	Pfam	PF14525	AraC-binding-like domain
26	198	InterPro	IPR035418	Transcription regulator HTH, AraC- type, ligand binding domain-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4094	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.857
2				0.314

PA4094