Protein profile

PA4114

spermidine acetyltransferase

Genome: NC_002516.2

Gene: PA4114 Structure source: AlphaFold UniProt Q9HWR6
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Amino acids 169
Annotations 2
Features 9
PDB binders 0
Druggability 0.932

Overview

Basic information about this protein and its source genome.

Accession
PA4114
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4114
Status
annotated
Amino acids
169
Structure source
AlphaFold
GO
GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule. GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.932
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008080 Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
47 96 CDD cd04301 NAT_SF
2 149 ProSiteProfiles PS51186 Gcn5-related N-acetyltransferase (GNAT) domain profile.
2 149 InterPro IPR000182 GNAT domain
2 133 PANTHER PTHR43420 ACETYLTRANSFERASE
43 128 Pfam PF00583 Acetyltransferase (GNAT) family
43 128 InterPro IPR000182 GNAT domain
1 146 Gene3D G3DSA:3.40.630.30 -
2 144 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
2 144 InterPro IPR016181 Acyl-CoA N-acyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4114
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.932
2 0.26