Protein profile

PA4116

heme oxygenase BphO

Genome: NC_002516.2

Gene: bphO PA4116 Structure source: AlphaFold UniProt Q9HWR4

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Amino acids 195

Annotations 2

Features 7

PDB binders 0

Druggability 0.825

Overview

Basic information about this protein and its source genome.

Accession: PA4116
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: bphO PA4116
Status: annotated
Amino acids: 195
Structure source: AlphaFold

GO:0004392 Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase]. GO:0006788 The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.825

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0004392 Catalysis of the reaction: heme b + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = biliverdin + CO + Fe2+ + H+ + 3 H2O + 3 oxidized [NADPH-hemoprotein reductase].
GO:0006788 The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme.

Sequence Features

Domain/signature hits from InterPro and related databases.

7 records

Show feature table

Start	End	DB	Term	Name
8	191	CDD	cd19166	HemeO-bac
2	192	Gene3D	G3DSA:1.20.910.10	-
2	192	InterPro	IPR016084	Haem oxygenase-like, multi-helical
9	192	Pfam	PF01126	Heme oxygenase
9	192	InterPro	IPR016053	Haem oxygenase-like
7	191	SUPERFAMILY	SSF48613	Heme oxygenase-like
7	191	InterPro	IPR016084	Haem oxygenase-like, multi-helical

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4116	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.825