Protein profile

PA4120

transcriptional regulator

Genome: NC_002516.2

Gene: PA4120 Structure source: AlphaFold UniProt Q9HWR1
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Amino acids 303
Annotations 4
Features 24
PDB binders 0
Druggability 0.564

Overview

Basic information about this protein and its source genome.

Accession
PA4120
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4120
Status
annotated
Amino acids
303
Structure source
AlphaFold
GO
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.564
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPERQPIPNINIGQVYDQRYADAEVHYDALGNLAGFFGRNMPAHRHDRFFQVHYVKNGAVRVYLDERQYLESGPMFFLTPPTVPHAFVTEADADGHVLTVRQQLVWSLTEAEPGLAPGPQVAPACVALGNLEGGAAEEAARLALLFEQLRSESMASRSGRQQALLALTRLVMISLLRLSANSVAARPMRHEDLQIFQRFNALIEERYAEHWPLSLYASRIGVTEARLNDVCRRIADLPSKRLVYERLMQESKRLLLFTGGSVNEICYQLGFKDPAYFSRFFVRYAGLTPSAYRQRQADGESRR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.

Sequence Features

Domain/signature hits from InterPro and related databases.

24 records
Show feature table
Start End DB Term Name
32 167 Pfam PF02311 AraC-like ligand binding domain
32 167 InterPro IPR003313 AraC-type arabinose-binding/dimerisation domain
7 295 NCBIfam TIGR02297 4-hydroxyphenylacetate catabolism regulatory protein HpaA
7 295 InterPro IPR011983 4-hydroxyphenylacetate catabolism regulatory protein HpaA
210 293 SMART SM00342 aracneu4
210 293 InterPro IPR018060 DNA binding HTH domain, AraC-type
248 295 SUPERFAMILY SSF46689 Homeodomain-like
248 295 InterPro IPR009057 Homeobox-like domain superfamily
191 302 Gene3D G3DSA:1.10.10.60 -
262 277 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
262 277 InterPro IPR020449 Transcription regulator HTH, AraC- type
277 293 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
277 293 InterPro IPR020449 Transcription regulator HTH, AraC- type
45 296 PANTHER PTHR43280 ARAC-FAMILY TRANSCRIPTIONAL REGULATOR
197 295 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
197 295 InterPro IPR018060 DNA binding HTH domain, AraC-type
38 120 SUPERFAMILY SSF51182 RmlC-like cupins
38 120 InterPro IPR011051 RmlC-like cupin domain superfamily
10 104 CDD cd06999 cupin_HpaA-like_N
10 104 InterPro IPR047264 HpaA-like, N-terminal cupin domain
37 106 Gene3D G3DSA:2.60.120.10 Jelly Rolls
37 106 InterPro IPR014710 RmlC-like jelly roll fold
216 295 Pfam PF12833 Helix-turn-helix domain
216 295 InterPro IPR018060 DNA binding HTH domain, AraC-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4120
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.549
2 0.243
4 0.224