Protein profile

PA4125

5-carboxymethyl-2-hydroxymuconate isomerase

Genome: NC_002516.2

Gene: hpcD PA4125 Structure source: AlphaFold UniProt Q9HWQ6

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Amino acids 130

Annotations 2

Features 10

PDB binders 0

Druggability 0.264

Overview

Basic information about this protein and its source genome.

Accession: PA4125
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: hpcD PA4125
Status: annotated
Amino acids: 130
Structure source: AlphaFold

GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.264

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0008704 Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate.
GO:0019439 OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records

Show feature table

Start	End	DB	Term	Name
1	128	Gene3D	G3DSA:3.30.429.10	Macrophage Migration Inhibitory Factor
1	128	InterPro	IPR014347	Tautomerase/MIF superfamily
2	114	CDD	cd00580	CHMI
2	114	InterPro	IPR004220	5-carboxymethyl-2-hydroxymuconate isomerase
2	124	Pfam	PF02962	5-carboxymethyl-2-hydroxymuconate isomerase
2	124	InterPro	IPR004220	5-carboxymethyl-2-hydroxymuconate isomerase
1	125	PANTHER	PTHR37950	4-HYDROXYPHENYLACETATE CATABOLISM PROTEIN
1	125	InterPro	IPR004220	5-carboxymethyl-2-hydroxymuconate isomerase
2	125	SUPERFAMILY	SSF55331	Tautomerase/MIF
2	125	InterPro	IPR014347	Tautomerase/MIF superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4125	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.264