Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4131
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4131
Status: annotated
Amino acids: 573
Structure source: AlphaFold

GO

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion. GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): Y
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.82

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5

GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
GO:0046872 Binding to a metal ion.
GO:0051536 Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms.

Sequence Features

Domain/signature hits from InterPro and related databases.

35 records

Show feature table

Start	End	DB	Term	Name
148	165	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
206	460	SUPERFAMILY	SSF54862	4Fe-4S ferredoxins
11	29	MobiDBLite	mobidb-lite	consensus disorder prediction
323	395	Gene3D	G3DSA:1.10.1060.10	-
323	395	InterPro	IPR009051	Alpha-helical ferredoxin
460	573	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
266	283	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
192	213	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
214	265	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
455	571	Pfam	PF11614	IG-like fold at C-terminal of FixG, putative oxidoreductase
455	571	InterPro	IPR032879	FixG, C-terminal immunoglobulin-like domain
303	320	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
363	392	ProSiteProfiles	PS51379	4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
363	392	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
266	288	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
323	393	FunFam	G3DSA:1.10.1060.10:FF:000015	Cytochrome c oxidase accessory protein CcoG
145	165	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	144	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
284	302	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
373	384	ProSitePatterns	PS00198	4Fe-4S ferredoxin-type iron-sulfur binding region signature.
373	384	InterPro	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site
192	214	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
142	570	NCBIfam	TIGR02745	cytochrome c oxidase accessory protein CcoG
142	570	InterPro	IPR014116	Cytochrome c oxidase cbb3 type, accessory protein FixG
320	426	Pfam	PF13746	4Fe-4S dicluster domain
320	426	InterPro	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain
146	429	PANTHER	PTHR30176	FERREDOXIN-TYPE PROTEIN NAPH
166	191	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
457	570	Gene3D	G3DSA:2.60.40.10	Immunoglobulins
457	570	InterPro	IPR013783	Immunoglobulin-like fold
1	29	MobiDBLite	mobidb-lite	consensus disorder prediction
321	440	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
441	459	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
441	458	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
303	320	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4131	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
3				0.82
30				0.214

PA4131