Protein profile

PA4142

secretion protein

Genome: NC_002516.2

Gene: PA4142 Structure source: AlphaFold UniProt Q9HWN9
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Amino acids 418
Annotations 0
Features 15
PDB binders 0
Druggability 0.904

Overview

Basic information about this protein and its source genome.

Accession
PA4142
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4142
Status
annotated
Amino acids
418
Structure source
AlphaFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.904
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

15 records
Show feature table
Start End DB Term Name
65 175 Gene3D G3DSA:2.40.50.100 -
1 23 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
113 158 Coils Coil Coil
187 224 Coils Coil Coil
229 256 Coils Coil Coil
24 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
275 403 Gene3D G3DSA:2.40.30.170 -
26 415 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
272 293 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
305 329 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
76 96 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
401 418 PRINTS PR01490 Gram-negative bacterial RTX secretion protein D signature
261 389 Pfam PF13437 HlyD family secretion protein
47 418 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
28 50 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4142
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
6 0.904
1 0.71
3 0.27