Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: PA4145a
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: YP_008719776.1
Status: annotated
Amino acids: 248
Structure source: ColabFold

GO

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: CytoplasmicMembrane

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.735

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MPVGFPCSVPGSGATPSVAPRQEPTEETHARPAPASPQSDRGVRPMPLALLLAMGAFSLSLSISPGPVNLTIVASGANHGFRRTLPFVTGATLGFVLLLAFVGFWFVRAIEAYPRFFDYLGMAGAAFIAHVGYRIATADPRLALEENGVPGFFQGVLLQWLNPKAWIACASGVALFASPSTHAPLLVFMAIYLVVCYLSLAAWALLGDRVALLLDSPRRVRLFNRAMGGTLVLTAGYMLYLQLAASPD

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2

GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0006865 The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records

Show feature table

Start	End	DB	Term	Name
48	65	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
207	225	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
156	178	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
246	248	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
85	107	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
185	207	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
108	118	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	39	MobiDBLite	mobidb-lite	consensus disorder prediction
46	240	PANTHER	PTHR30086	ARGININE EXPORTER PROTEIN ARGO
46	240	InterPro	IPR001123	Amino acid exporter protein, LeuE-type
185	206	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
119	136	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
137	184	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
226	245	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
222	244	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
119	136	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
66	84	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
85	107	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	47	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
48	70	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
59	240	Pfam	PF01810	LysE type translocator
59	240	InterPro	IPR001123	Amino acid exporter protein, LeuE-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
ColabFold PA4145A	ColabFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.735
4				0.602

PA4145a