Protein profile

PA4154

hypothetical protein

Genome: NC_002516.2

Gene: PA4154 Structure source: AlphaFold UniProt Q9HWM7
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Amino acids 222
Annotations 1
Features 23
PDB binders 0
Druggability 0.852

Overview

Basic information about this protein and its source genome.

Accession
PA4154
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4154
Status
annotated
Amino acids
222
Structure source
AlphaFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.852
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records
Show feature table
Start End DB Term Name
189 211 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
41 104 SMART SM00287 sh3_bac_9
41 104 InterPro IPR003646 SH3-like domain, bacterial-type
1 17 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
18 29 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
189 211 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 36 Phobius SIGNAL_PEPTIDE Signal peptide region
41 105 ProSiteProfiles PS51781 SH3b domain profile.
41 105 InterPro IPR003646 SH3-like domain, bacterial-type
15 222 PIRSF PIRSF006158 UCP006158_SH3
15 222 InterPro IPR016476 SH3 domain protein
53 101 Pfam PF08239 Bacterial SH3 domain
53 101 InterPro IPR003646 SH3-like domain, bacterial-type
1 36 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
212 222 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
37 188 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 36 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
139 177 Coils Coil Coil
45 221 NCBIfam TIGR04211 TIGR04211 family SH3 domain-containing protein
45 221 InterPro IPR016476 SH3 domain protein
40 107 Gene3D G3DSA:2.30.30.40 SH3 Domains
30 36 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
111 131 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4154
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.852
3 0.556
1 0.375