Protein profile

PA4159

iron-enterobactin transporter periplasmic binding protein

Genome: NC_002516.2

Gene: PA4159 fepB Structure source: AlphaFold UniProt Q9HWM2
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Amino acids 301
Annotations 2
Features 17
PDB binders 3
Druggability 0.703

Overview

Basic information about this protein and its source genome.

Accession
PA4159
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4159 fepB
Status
annotated
Amino acids
301
Structure source
AlphaFold
GO
GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Gut microbiome off-target
hit
Essential (DEG)
Y
Localization
Periplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.703
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

MPTRRRSALPLLALALSLFAILAAAGEPKPARIVSTTPSVTGILLAMDAPLVASAATTPSRLTDAKGFFSQWAKVADQRGVEVLYRNLRFDIEAVIAQDPDLLVASATGADSAAPYRAELEAQGVPTLVVDYSKHSWQELATELGRHTGLERQAQAAIQRFDAYTAEVAAAIAPPQGPVSVVGYNIAGSYSIGRQASPQARLLEALGFQVAELPEALAGKVTRASDFQFISRENLPAAIAGDSVFLLGASDDDVQAFLADPVLANLSAVREKRVYALGPSSFRIDYYSGRQMIDNVARHFR

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0030288 The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
  • GO:1901678 The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
1 7 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
25 130 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
1 25 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
32 301 ProSiteProfiles PS50983 Iron siderophore/cobalamin periplasmic-binding domain profile.
32 301 InterPro IPR002491 ABC transporter periplasmic binding domain
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
29 294 CDD cd01146 FhuD
1 25 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
131 301 Gene3D G3DSA:3.40.50.1980 Nitrogenase molybdenum iron protein domain
33 279 Pfam PF01497 Periplasmic binding protein
33 279 InterPro IPR002491 ABC transporter periplasmic binding domain
29 300 PANTHER PTHR30532 IRON III DICITRATE-BINDING PERIPLASMIC PROTEIN
8 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 26 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
25 301 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
29 287 SUPERFAMILY SSF53807 Helical backbone metal receptor

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4159
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.703
3 0.592
2 0.337

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

53 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
7PG
5FLY
A0A2P5JFB2 384.5 Da LogP -0.26 TPSA 94.1 ✓ Ro5 ✓ Clean COCCOCCOCCOCCOCCOCCOCCOCCO
EB4
3TLK
P0AEL6 669.6 Da LogP -0.74 TPSA 287.6 3 viol. Alert c1cc(c(c(c1)O)O)C(=O)N[C@H]2COC(=O)[C@H](COC(=O…
VBN
3R5T
Q9RCF6 705.7 Da LogP 1.84 TPSA 243.1 3 viol. Alert C[C@@H]1[C@H](N=C(O1)c2cccc(c2O)O)C(=O)NCCCN(CC…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.