Protein profile

PA4169

hypothetical protein

Genome: NC_002516.2

Gene: PA4169 Structure source: AlphaFold UniProt Q9HWL2

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Amino acids 142

Annotations 3

Features 11

PDB binders 0

Druggability 0.573

Overview

Basic information about this protein and its source genome.

Accession: PA4169
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4169
Status: annotated
Amino acids: 142
Structure source: AlphaFold

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.573

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records

Show feature table

Start	End	DB	Term	Name
1	140	FunFam	G3DSA:1.10.10.10:FF:000138	Rrf2 family transcriptional regulator
3	136	SUPERFAMILY	SSF46785	Winged helix DNA-binding domain
3	136	InterPro	IPR036390	Winged helix DNA-binding domain superfamily
1	139	PANTHER	PTHR33221	WINGED HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, RRF2 FAMILY
1	139	InterPro	IPR000944	Transcription regulator Rrf2
5	133	Pfam	PF02082	Iron-dependent Transcriptional regulator
5	133	InterPro	IPR000944	Transcription regulator Rrf2
2	133	ProSiteProfiles	PS51197	Rrf2-type HTH domain profile.
2	133	InterPro	IPR000944	Transcription regulator Rrf2
1	139	Gene3D	G3DSA:1.10.10.10	-
1	139	InterPro	IPR036388	Winged helix-like DNA-binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4169	AlphaFold	—	—	full sequence	—	Viewing

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Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
4				0.573