Protein profile

PA4181

hypothetical protein

Genome: NC_002516.2

Gene: PA4181 Structure source: AlphaFold UniProt Q9HWK0

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Amino acids 239

Annotations 2

Features 8

PDB binders 0

Druggability 0.719

Overview

Basic information about this protein and its source genome.

Accession: PA4181
Assembly: Pseudomonas aeruginosa PAO1, complete genome
Gene: PA4181
Status: annotated
Amino acids: 239
Structure source: AlphaFold

GO:0004826 Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0003723 Binding to an RNA molecule or a portion thereof.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Gut microbiome off-target: hit
Essential (DEG): N
Localization: Unknown

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.719

Structure –

Pocket –

Sequence

Primary amino-acid sequence viewer.

MPEHAPILPVIAAEVAALAPGFRALSLTVEAAPIVRPEIAGRAVERACQALARGEPDWAEAHLAAWAEAFRRFGAKPQRTPCSAEALRKRALRDGGLPSIDPVVDLYNAISVQFAIPVGGENLAAYAGPPRLVVADGSETFDTLKNGEALDESPDPGEVVWRDDLGVTCRRWNWRQGVRTRLDASARRMWFILESLPEMPLAALHEAGGLLLDELRLMMPGMRADSRLLCVATESADSV

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

GO:0004826 Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
GO:0003723 Binding to an RNA molecule or a portion thereof.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records

Show feature table

Start	End	DB	Term	Name
11	230	PANTHER	PTHR39209	-
64	216	SMART	SM00873	B3_4_2
64	216	InterPro	IPR005146	B3/B4 tRNA-binding domain
54	213	SUPERFAMILY	SSF56037	PheT/TilS domain
73	197	Gene3D	G3DSA:3.50.40.10	-
73	197	InterPro	IPR020825	Phenylalanyl-tRNA synthetase-like, B3/B4
66	195	Pfam	PF03483	B3/4 domain
66	195	InterPro	IPR005146	B3/B4 tRNA-binding domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold PA4181	AlphaFold	—	—	full sequence	—	Viewing

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.719