Protein profile

PA4188

hypothetical protein

Genome: NC_002516.2

Gene: PA4188 Structure source: AlphaFold UniProt Q9HWJ3
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Amino acids 303
Annotations 3
Features 19
PDB binders 10
Druggability 0.854

Overview

Basic information about this protein and its source genome.

Accession
PA4188
Assembly
Pseudomonas aeruginosa PAO1, complete genome
Gene
PA4188
Status
annotated
Amino acids
303
Structure source
AlphaFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008840 Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+. GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
27.404
Human E-value
1.65e-11
Gut microbiome off-target
hit
Essential (DEG)
N
Localization
Cytoplasmic

Selected Druggability evidence

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.854
Structure –
Pocket –

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008840 Catalysis of the reaction: L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H+.
  • GO:0016829 Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
2 290 SMART SM01130 DHDPS_2
2 290 InterPro IPR002220 DapA-like
1 289 SUPERFAMILY SSF51569 Aldolase
1 299 PIRSF PIRSF001365 DHDPS
1 299 InterPro IPR002220 DapA-like
1 290 Gene3D G3DSA:3.20.20.70 Aldolase class I
1 290 InterPro IPR013785 Aldolase-type TIM barrel
2 290 PANTHER PTHR12128 DIHYDRODIPICOLINATE SYNTHASE
6 286 CDD cd00408 DHDPS-like
36 57 PRINTS PR00146 Dihydrodipicolinate synthase signature
36 57 InterPro IPR002220 DapA-like
129 146 PRINTS PR00146 Dihydrodipicolinate synthase signature
129 146 InterPro IPR002220 DapA-like
72 90 PRINTS PR00146 Dihydrodipicolinate synthase signature
72 90 InterPro IPR002220 DapA-like
104 120 PRINTS PR00146 Dihydrodipicolinate synthase signature
104 120 InterPro IPR002220 DapA-like
2 287 Pfam PF00701 Dihydrodipicolinate synthetase family
2 287 InterPro IPR002220 DapA-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold PA4188
AlphaFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.854
2 0.437

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

60 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
2KT
3TDF
D0CFC3 102.1 Da LogP 0.05 TPSA 54.4 ✓ Ro5 ✓ Clean CCC(=O)C(=O)O
GXP
4OE7
P75682 146.1 Da LogP -1.41 TPSA 91.7 ✓ Ro5 ✓ Clean C([C@@H](C=O)O)C(=O)C(=O)O
GXT
4OE7
P75682 58.0 Da LogP -0.62 TPSA 34.1 ✓ Ro5 ✓ Clean C(=O)C=O
GXV
4PTN
P75682 90.1 Da LogP -1.46 TPSA 57.5 ✓ Ro5 ✓ Clean C([C@@H](C=O)O)O
KDG
4ONV
P75682 178.1 Da LogP -2.26 TPSA 115.1 ✓ Ro5 ✓ Clean C([C@@H]([C@@H](CO)O)O)C(=O)C(=O)O
LYZ
3TCE
D0CFC3 162.2 Da LogP -1.50 TPSA 109.6 ✓ Ro5 ✓ Clean C(C[C@@H](C(=O)O)N)[C@H](CN)O
MLT
3IRD
A5I6N2 134.1 Da LogP -1.09 TPSA 94.8 ✓ Ro5 ✓ Clean C([C@H](C(=O)O)O)C(=O)O
OXL
3U8G
D0CFC3 88.0 Da LogP -3.51 TPSA 80.3 ✓ Ro5 ✓ Clean C(=O)(C(=O)[O-])[O-]
PYR
3RK8
D0CFC3 88.1 Da LogP -0.34 TPSA 54.4 ✓ Ro5 ✓ Clean CC(=O)C(=O)O
RSH
3NEV
P75682 180.2 Da LogP -2.46 TPSA 118.2 ✓ Ro5 ✓ Clean C([C@H]([C@@H](CO)O)O)[C@@H](C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.